Repeated bouts of aerobic exercise lead to reductions in skeletal muscle free radical generation and nuclear factor κB activation

Repeated bouts of aerobic exercise lead to reductions in skeletal muscle free radical generation and nuclear factor kappaB activation.

Chronic exercise improves endurance and skeletal muscle oxidative capacity. Despite the potential importance of reactive oxygen species (ROS) generated during exercise as regulators of these adaptations, the effect of repeated bouts of aerobic exercise on ROS generation by skeletal muscles during contractions has not been examined. Our aim was to establish the impact of repeated treadmill runni...

Human growth hormone response to repeated bouts of aerobic exercise.

We examined whether repeated bouts of exercise could override growth hormone (GH) auto-negative feedback. Seven moderately trained men were studied on three occasions: a control day (C), a sequential exercise day (SEB; at 1000, 1130, and 1300), and a delayed exercise day (DEB; at 1000, 1400, and 1800). The duration of each exercise bout was 30 min at 70% maximal O2 consumption (VO2max) on a cyc...

Impact of Repeated Bouts of Eccentric Exercise on Skeletal Muscle Morphology and Myogenic Gene Expression

Aging and acute exercise enhance free radical generation in rat skeletal muscle.

Reactive oxygen species (ROS) are implicated in the mechanism of biological aging and exercise-induced oxidative damage. The present study examined the effect of an acute bout of exercise on intracellular ROS production, lipid and protein peroxidation, and GSH status in the skeletal muscle of young adult (8 mo, n = 24) and old (24 mo, n = 24) female Fischer 344 rats. Young rats ran on a treadmi...

Free radical generation by cultured mouse skeletal muscle cells

It has been extensively reported that free radical species are generated by contracting skeletal muscle following different exercise protocols (O’Neill et al. 1996; Reznick et al. 1996; McArdle et al. 2001), including non-damaging contractions (McArdle et al. 2001). However, numerous non-muscle cells are found in skeletal muscle in vivo and the presence of these cells has complicated the interp...